Francesco Gentile

 

Gentile

       

        Doctor of Philosophy in Biophysics (Current)
        University of Alberta, Alberta, Canada

        Master of Science in Biomedical Engineering
        Politecnico di Torino, Turin, Italy

        Bachelor of Science in Biomedical Engineering
        Politecnico di Torino, Turin, Italy 

 

 

Projects:

My current research focuses on the use of computational biophysics techniques to study protein complexes involved in DNA repair. Also, I apply ligand and structure-based drug design methods to discover small molecules able to inhibit the repair of platinum and radiation-induced DNA damage in cancer cells, in order to improve the potency of cancer treatment and overcome drug resistance. I am also interested in enhanced sampling techniques applied to Molecular Dynamics simulations.

 

Academic networks:

 

Publications:

  1. Sheff JG, Farshidfar F, Bathe OF, et al. Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data. Mol Cell Proteomics 2017; 16: 428–37.

  2. Gentile F, Tuszynski JA, Barakat KH. Modelling DNA Repair Pathways: Recent Advances and Future Directions. Curr Pharm Des 2016; 22: 3527–46.

  3. Gentile F, Tuszynski JA, Barakat KH. New Design of Nucleotide Excision Repair (NER) Inhibitors for Combination Cancer Therapy. J Mol Graph Model 2016; 65: 71–82.

  4. Gentile F, Deriu MA, Licandro G, Prunotto A, Danani A, Tuszynski JA. Structure Based Modeling of Small Molecules Binding to the TLR7 by Atomistic Level Simulations. Molecules 2015; 20: 8316–40.

  5. Tuszynski JA, Winter P, White D, et al. Mathematical and computational modeling in biology at multiple scales. Theor Biol Med Model 2014; 11: 52.